Thalitone; Descriptions. What is chlorthalidone (Hygroton, Thalitone)? "Chlorthalidone." As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. [1] It is also used to prevent calcium-based kidney stones. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. Grim on brand name for chlorthalidone: Normal BP in a 29yo is 750 mg. Chlorthalidone has a much longer half-life compared to HCTZ (mg/mg) (44 hours, chlorthalidone vs. 12 hours, hydrochlorothiazide) and indapamide is 10 times more potent. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. In Analytical Profiles of Drug Substances, vol. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. National Center for Biotechnology Information. [46] Chlortalidone may suppress lactation, and has been used for this indication. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. [47], Chlortalidone is in the sulfamoylbenzamide class. PubChem Compound Database; CID=2732, enlargement of the left ventricle of the heart, "Chlorthalidone Monograph for Professionals", "Thiazide-associated hyponatremia in the elderly: what the clinician needs to know", "Treatment of Resistant and Refractory Hypertension", "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis", "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis", "Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic", "Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline", "Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD", "Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone", "Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial", "Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline", "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis", "A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Clorpres; Descriptions. Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. chlorthalidone systemic. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to … Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. Brand names: Diuril, Diuril Sodium. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. Highlights for chlorthalidone. The frequency and severity of these adverse effects is much reduced when chlortalidone is used at lower doses (e.g., 12.5 mg per day). Anuria. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. High Blood Pressure. Drug class (es): thiazide diuretics. [7][8] While it may be used in pregnancy it is a less preferred option. Chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg wi MedChem Express HY-15833: Membrane Tranporter/Ion Channel MedChem Express HY-15833 [19] Chlortalidone is superior to angiotensin converting enzyme Inhibitors or angiotensin II receptor blockers for inducing regression of enlargement of the left ventricle, which is the main pumping chamber of the heart. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … 14, pp. Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. [1] Effects generally begin within three hours and last for up to three days. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. [1][2][3] Other side effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets [1] It is specifically a thiazide-like diuretic. [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. [9] It is available as a generic medication. [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. More Info about Chlorthalidone. noun a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks • Syn: ↑Hygroton, ↑Thalidone • Hypernyms: ↑diuretic drug, ↑diuretic,… Liver disease: There is a risk of precipitating hepatic encephalopathy in patients with liver cirrhosis and ascites. The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. Chlorthalidone systemic is used in the treatment of: Edema. [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). 100 2. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. [10][11], Chlortalidone is considered a first-line medication for treatment high blood pressure. chlorothiazide systemic. Cautions. [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. 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